PF 5081090 is a potent antibacterial agent which disrupts lipid bilayer synthesis through inhibition of LpxC with IC50 of 1.1 nM in Pseudomonas aeruginosa.

ACHN-975 TFA is a selective LpxC inhibitor and exhibits a subnanomolar LpxC inhibitory activity. ACHN-975 TFA is against a wide range of gram-negative bacterias with low MIC values (≤1 μg/mL)[1].