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首頁 / / / / Germacrone/吉馬酮

Germacrone/吉馬酮 {[allProObj[0].p_purity_real_show]}

貨號：A578841 同義名： 牻牛兒酮 / (E,E)-Germacrone

Germacrone是一種從姜黃中提取的天然產物，具有抗腫瘤活性，能夠通過線粒體途徑誘導乳腺癌細胞凋亡。

Germacrone/吉馬酮化學結構
CAS號：6902-91-6

Germacrone/吉馬酮 3D分子結構
CAS號：6902-91-6

規格	價格	會員價	庫存	數量
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產品信息一鍵復制 購物車0 收藏詢單

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Germacrone/吉馬酮純度/質量文件產品僅供科研

貨號：A578841 標準純度： {[allProObj[0].p_purity_real_show]} 產品說明書

批次查詢：批次純度: COA SDS NMR HPLC CNMR LC-MS

全球學術期刊中引用的產品: ? Nature, 2026. Ambeed. [ A116360 ]; ? Nature, 2026, 651, 211-220. Ambeed. [ A111216 , A291101 , A169647 , A115820 , A113480 , A635338 , A139877 , A258659 ]; ? Cell Metab., 2026. Ambeed. [ A172341 , A394054 ]; ? Adv. Mater., 2026, e11078. Ambeed. [ A1680754 ]; ? Adv. Mater., 2026, e17774. Ambeed. [ A551995 ]; 更多 >

5-alpha還原酶亞型比較
脫氫酶亞型比較
NF-κB 亞型比較

產品名稱	5-alpha Reductase ↓ ↑	純度
Dutasteride	?	99%
Finasteride	+++ 5-α reductase, Ki: 10.2 nM	98%
1. 鼠標懸停在“+”上可以顯示相關IC50的具體數值。"+"越多，抑制作用越強。2. "?"表示該化合物對相應的亞型有抑制作用，但抑制強度暫時沒有相關數據。

產品名稱	Dehydrogenase ↓ ↑	純度
Trilostane	?	99+%
AGI-6780	+++ IDH2 R140Q mutant, IC50: 23 nM	99%+
Gimeracil	?	98%
AGI-5198	++ R132C-IDH1, IC50: 0.16 μM R132H-IDH1, IC50: 70 nM	99%+
SW033291	++++ 15-PGDH, IC50: 1.5 nM 15-PGDH, Ki: 0.1 nM	99%+
Mycophenolic acid	?	99+%
Fomepizole	?	98%
Leflunomide	?	98%
3-Nitropropanoic acid	?	99%+
Isovaleramide	?	99%
Mycophenolate Mofetil	+++ Inosine monophosphate dehydrogenase II, IC50: 27 nM Inosine monophosphate dehydrogenase I, IC50: 39 nM	98%
MK-8245	++++ SCD1 (rat), IC50: 3 nM SCD1 (mouse), IC50: 1 nM	99%+
Vidofludimus	++ Human DHODH, IC50: 134 nM	99%+
Emodin	?	98%
Ivosidenib	?	98%
NCT-501	++ ALDH1A1, IC50: 40 nM	98%
Gossypol	?	99%+
Devimistat	?	98%
Disulfiram	?	98%+
Enasidenib	++++ IDH2, IC50: 12 nM	98%
PluriSIn 1	?	99%+
ML390	+ DHODH, IC50: 0.56 μM	99%+
Teriflunomide	?	99%+
Daidzin	+++ ALDH-Ⅰ, Ki: 20 nM	98+%
18β-Glycyrrhetinic acid	?	99%
RRx-001	?	95%
NCT-503	+ PHGDH, IC50: 2.5 μM	99%+
Vorasidenib	?	99%+
Ammonium Glycyrrhizinate(x:1)	?	98+%
1. 鼠標懸停在“+”上可以顯示相關IC50的具體數值。"+"越多，抑制作用越強。2. "?"表示該化合物對相應的亞型有抑制作用，但抑制強度暫時沒有相關數據。

產品名稱	NF-κB ↓ ↑	其他靶點	純度
Ammonium pyrrolidine-1-carbodithioate	?		98%
QNZ	++++ NF-κB, IC50: 11 nM		99%+
Sodium 4-Aminosalicylate Dihydrate	?		98%
Sodium Salicylate	?		95%
Parthenolide	?	p53	97% HPLC
JSH-23	+ NF-κB, IC50: 7.1 μM		98%
Phenethyl caffeate	?		98% (E)
Andrographolide	?		98+%
Curcumin	?	Nrf2,HDAC	98%
SC75741	+++ NF-κB, EC50: 200 nM		99%+
CBL0137 HCl	++ NF-κB, EC50: 0.47 μM	p53	99%+
1. 鼠標懸停在“+”上可以顯示相關IC50的具體數值。"+"越多，抑制作用越強。2. "?"表示該化合物對相應的亞型有抑制作用，但抑制強度暫時沒有相關數據。

Germacrone/吉馬酮生物活性

描述

Germacrone, a natural product isolated and purified from the rhizoma of Curcuma wenyujin with anti-tumor activity, can inhibit the proliferation of breast cancer cell lines by inducing cell cycle arrest and apoptosis through mitochondria-mediated caspase pathway, and may be a potent chemopreventive drug candidate for liver cancer via regulating the expression of proteins related to G2/M cell cycle and apoptosis, and p53 and oxidative damage may play important roles in the inhibition of human hepatoma cells growth by germacrone.

Germacrone/吉馬酮細胞實驗

Cell Line Differentiated HepaRG cells Differentiated HepaRG cells LO2 cells LX-2 cells GES-1 cells MGC 803 cells AGS cells IEC-6 cells HepG2 cells	Concentration	Treated Time	Description	References
Differentiated HepaRG cells	100 μM	1, 6, 12, 24 hours	To evaluate the effect of Germacrone on reactive oxygen species (ROS) production in HepaRG cells, results showed that Germacrone significantly increased ROS production at 100 μM.	Nutrients. 2020 Jun 8;12(6):1720.
Differentiated HepaRG cells	250 μM	24 hours	To evaluate the effect of Germacrone on the viability of HepaRG cells, results showed that Germacrone significantly inhibited cell viability at 250 μM.	Nutrients. 2020 Jun 8;12(6):1720.
LO2 cells	10-40 μM	12 hours	GER protects hepatocytes by inhibiting APAP-induced mitochondrial ROS release	Front Pharmacol. 2021 Oct 5;12:745561.
LX-2 cells	60-120 μM	24 hours	GER promotes HSC apoptosis by upregulating cleaved-caspase 3 protein expression and inhibiting anti-apoptotic protein Bcl-2 expression	Front Pharmacol. 2021 Oct 5;12:745561.
GES-1 cells	7.89%	24, 48, 72 hours	To investigate the effect of Germacrone on the proliferation of GES-1 cells, results showed that high concentrations ( ≥90μg/mL) of zedoary oil killed GES-1 cells.	Chin Med. 2013 Jun 28;8:13.
MGC 803 cells	7.89%	24, 48, 72 hours	To investigate the effect of Germacrone on the proliferation of MGC 803 cells, results showed that zedoary oil significantly decreased the cell viability of MGC 803 cells.	Chin Med. 2013 Jun 28;8:13.
AGS cells	7.89%	24, 48, 72 hours	To investigate the effect of Germacrone on the proliferation of AGS cells, results showed that zedoary oil significantly decreased the cell viability of AGS cells.	Chin Med. 2013 Jun 28;8:13.
IEC-6 cells	1, 2, 4 μM	24 hours	Germacrone significantly upregulated the mRNA expression of HO-1 and NQO1 in IEC-6 cells and significantly increased the mRNA expression of ZO-1 and Occludin to alleviate ethanol-induced intestinal barrier injury.	Front Pharmacol. 2022 Sep 26;13:981706.
HepG2 cells	0.5, 1, 2 μM	24 hours	Germacrone significantly downregulated the mRNA transcription of NQO1 in HepG2 cells, and GM-H reduced the expression of HO-1, while the protein expression of HO-1 showed a similar trend.	Front Pharmacol. 2022 Sep 26;13:981706.

Germacrone/吉馬酮動物實驗

Species Sprague-Dawley rats C57BL/6 mice	Animal Model Adjuvant-induced arthritis (AIA) rat model MCD diet-induced liver fibrosis model	Administration	Dosage	Frequency	Description	References
Sprague-Dawley rats	Adjuvant-induced arthritis (AIA) rat model	Tail vein injection	8 mg/kg GER	Administered on days 16, 18, 20, 22, and 24	Evaluate the therapeutic effect of FA-NPs/GER in AIA rats, results showed that FA-NPs/GER significantly reduced the swelling and inflammation infiltration of the rat’s foot and decreased the levels of pro-inflammatory cytokines (TNF-α, IL-1β).	Drug Deliv. 2022 Dec;29(1):692-701.
C57BL/6 mice	MCD diet-induced liver fibrosis model	Intragastric gavage	25 or 50 mg/kg	Once daily for 6 weeks	GER ameliorates MCD diet-induced liver fibrosis by inhibiting the TGF-β/Smad signaling pathway	Front Pharmacol. 2021 Oct 5;12:745561.

Germacrone/吉馬酮參考文獻

[1]An JF, Sun Y, et al. The effects of germacrone on lipopolysaccharide-induced acute lung injury in neonatal rats. Cell Mol Biol (Noisy-le-grand). 2014 Nov 16;60(4):8-12.

[2]Xie XH, Zhao H, et al. Germacrone reverses Adriamycin resistance through cell apoptosis in multidrug-resistant breast cancer cells. Exp Ther Med. 2014 Nov;8(5):1611-1615. Epub 2014 Aug 26.

Germacrone/吉馬酮實驗方案

計算器

存儲液制備

1mg

5mg

10mg

1 mM

5 mM

10 mM

4.58mL

0.92mL

0.46mL

22.90mL

4.58mL

2.29mL

45.80mL

9.16mL

4.58mL

Germacrone/吉馬酮技術信息

CAS號	6902-91-6
分子式	C₁₅H₂₂O
分子量	218.33
SMILES Code	C/C(C)=C1C/C=C(C)/CC/C=C(C)/CC\1=O
MDL No.	MFCD00210050

別名	牻牛兒酮 ;(E,E)-Germacrone
英文名稱	(3E,7E)-3,7-Dimethyl-10-(propan-2-ylidene)cyclodeca-3,7-dien-1-one
運輸	藍冰

存儲條件

In solvent -20°C: 3-6個月 -80°C: 12個月

Pure form Sealed in dry, 2-8°C

溶解方案

細胞實驗：

DMSO 中的溶解度 : 100 mg/mL (458.02 mM; 超聲助溶; 吸濕的 DMSO 對產品的溶解度有顯著影響，請使用新開封的 DMSO)

動物實驗：請根據您的動物給藥指南選擇適當的溶解方案。
以下溶解方案都請先按照體外實驗的方式配制澄清的儲備液，再依次添加助溶劑：
——為保證實驗結果的可靠性，澄清的儲備液可以根據儲存條件，適當保存；體內實驗的工作液，建議現用現配，當天使用；以下溶劑前顯示的百分比是指該溶劑在終溶液中的體積占比；如在配制過程中出現沉淀、析出現象，可以通過加熱和/或超聲的方式助溶

方案一

方案二

方案三

靶點

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