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規(guī)格	價格	會員價	庫存	數量
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Cell Line Human peripheral blood mononuclear cells (hPBMC) T cells	Concentration	Treated Time	Description	References
Human peripheral blood mononuclear cells (hPBMC)	500 nmol/L	20 hours	To evaluate the effect of PF-06650833 on cytokine secretion after LPS stimulation. Results showed that PF-06650833 effectively reduced the secretion of inflammatory cytokines such as IL-1, IFN-γ, TNF-α, and IL-17.	Biomed Pharmacother. 2022 Sep;153:113459.
T cells	20 μM	96 hours	To evaluate the effect of PF-06650833 on T cell proliferation and IFN-γ production, results showed that PF-06650833 significantly suppressed IFN-γ production by T cells without affecting their proliferation.	Haematologica. 2020 Jan;105(1):226-234.

Species Mice Female Balb/c mice Mice HuNOG-EXL mice Balb/c mice	Animal Model Λ-carrageenan-induced paw edema and DSS-induced ulcerative colitis Inhaled lipopolysaccharide (LPS)-induced ARDS mouse model Graft-versus-host disease model CD34+ hematopoietic stem cell-engrafted NOG-EXL mice Inhaled LPS-induced ARDS mouse model	Administration	Dosage	Frequency	Description	References
Mice	Λ-carrageenan-induced paw edema and DSS-induced ulcerative colitis	Intravenous injection	23 mg/kg	Every other day for a total of four injections	To evaluate the accumulation and anti-inflammatory effects of VCAM1-targeted nanocarriers in inflamed tissues. Results demonstrated that VCAM1-targeted nanocarriers significantly reduced paw edema and colitis symptoms, decreased proinflammatory cytokine levels in affected tissues, and showed no apparent systemic toxicity.	Small. 2024 Jan;20(4):e2306270
Female Balb/c mice	Inhaled lipopolysaccharide (LPS)-induced ARDS mouse model	Oral	100 mg/kg	Preventive administration: one dose 30 min before modeling and another dose 6h after modeling; Therapeutic administration: two doses at 4 h and 12 h after modeling.	To evaluate the therapeutic effect of PF-06650833 in the ARDS model. Results showed that although PF-06650833 exhibited excellent IRAK4 inhibitory activity in vitro, it failed to significantly alleviate lung injury or reduce inflammatory cell infiltration in the in vivo model.	Biomed Pharmacother. 2022 Sep;153:113459.
Mice	Graft-versus-host disease model	Intravenous injection	12.0 mg/kg	Once daily for 20 days	To evaluate the effect of PF-06650833 on graft-versus-host disease, results showed that PF-06650833 significantly ameliorated morbidity and mortality of GvHD.	Haematologica. 2020 Jan;105(1):226-234.
HuNOG-EXL mice	CD34+ hematopoietic stem cell-engrafted NOG-EXL mice	Oral	100 mg/kg	Single dose, 30 minutes prior to challenge	Evaluate the inhibitory effect of PF-06650833 on AZ617-induced human TNFα, significantly reducing circulating human TNFα	J Biol Methods. 2023 Nov 20;10:jbm-10-e99010008
Balb/c mice	Inhaled LPS-induced ARDS mouse model	Oral	100 mg/kg	Preventive administration: single dose 30 min before modeling; Therapeutic administration: twice at 4 h and 12 h after LPS modeling	To evaluate the therapeutic effect of PF-06650833 in ARDS model. Results showed PF-06650833 failed to significantly improve lung injury scores and inflammatory cell infiltration, performing worse compared to BAY-1834845.	Biomed Pharmacother. 2022 Sep;153:113459

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摩爾計算器

計算溶液所需的質量，體積或濃度。 Ambeed 摩爾濃度計算器基于以下方程式：

濃度 (mol/L) × 體積 (L) × 分子量 (g/mol)=質量 (g)

濃度

體積

分子量

質量

*在制備母液時，請始終參考產品標簽或 MSDS / COA（在產品頁面可下載）上所顯示的對應批次產品的分子量。

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CAS號	1817626-54-2
分子式	C₁₈H₂₀FN₃O₄
分子量	361.37
SMILES Code	O=C(C1=CC2=C(C(OC[C@H]([C@H](CC)[C@@H]3F)NC3=O)=NC=C2)C=C1OC)N
MDL No.	MFCD30343869

別名	PF-06650833
英文名稱	1-(((2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl)methoxy)-7-methoxyisoquinoline-6-carboxamide
運輸	藍冰
InChI Key	JKDGKIBAOAFRPJ-ZBINZKHDSA-N
Pubchem ID	118414016

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