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全部(20) Inhibitor(2)
GSK 650394是一種 SGK1 和 SGK2 抑制劑,IC50 分別為 62 nM 和 103 nM,能夠抑制流感病毒復制,可用于多種疾病研究。
EMD638683是一種高度選擇性的SGK1抑制劑,IC50值為3 μM。
URMC-099是一種口服生物可利用、腦滲透性強的混合譜激酶 3(MLK3)抑制劑,IC50 為 14 nM,能夠抑制小膠質細胞中 LPS 引起的 TNFα 釋放、HIV-1 Tat 引起的細胞因子釋放及小鼠腦內磷酸化 JNK 上調。
RO-3306是一種強效且選擇性的 CDK1 抑制劑,對 CDK1/cyclin B1 的 Ki 值為 35 nM,選擇性是 CDK2/cyclin E 和 CDK4/cyclin D 的 10 倍和 50 倍以上。
HaloPROTAC-E is a novel HaloPROTAC potent degrader, inducing reversible degradation of two endosomally localized proteins, SGK3 and VPS34, with a DC50 of 3-10 nM, remarkably selective inducing only degradation of the Halo tagged endogenous VPS34 complex (VPS34, VPS15, Beclin1, and ATG14) and no other proteins were significantly degraded.
EMD638683 R-form is the R-form of EMD638683, which is a highly selective SGK1 inhibitor with IC50 of 3 μM.
EMD638683 S-form is the S-form of EMD638683. EMD638683 is a highly selective SGK1 inhibitor with IC50 of 3 μM.
SGK1-IN-1 is a highly active and selective inhibitor of SGK-1, with an IC50 of 1 nM.
BRD7398 is a RSK kinase inhibitor that induces insulin expression and differentiation of pancreatic alpha into beta cells. It inhibits RSK1, RSK2 and RSK3 with IC50 values of 1.5, 2.4 and 1.2 uM, respectively.
AT13148 is an oral, ATP-competitive, multi-AGC kinase inhibitor with IC50 of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM for Akt1/2/3, p70S6K, PKA, and ROCKI/II, respectively.
Tags: SGK | 代謝酶 | Metabolic Enzyme | PPAR Signaling Pathway | SGK 相關產品
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